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Next-generation sequencing has yielded a wealth of biological data, but perhaps none as important as abnormalities in the genes that drive the development and growth of many types of cancer. Over the past decade, large-scale research projects have begun to survey and catalog the genomic changes associated with a variety of cancers. Still, some tumor types have not been deeply characterized. New technologies and the knowledge gained from genomic studies could be used to define the full set of driver mutations in many cancers.