FastID and TachysSTR

Organization: MIT Lincoln Laboratory
Year: 2018

Genetic differences in DNA can be useful for detecting a few cancerous cells hidden in normal tissues or distinguishing between different individuals as a DNA fingerprint. The two common types of DNA variants are short tandem repeats (STRs)— a short segment of DNA that occurs multiple times in a series—and single nucleotide polymorphisms (SNPs)—a single DNA base at a location that is different between cells or individuals. STRs and SNPs are used widely today for human identity testing applications, including forensic DNA analysis. FastID and TachysSTR are algorithms that implement rapid identification and mixture analysis searches of very large forensic profile databases for both STRs (using FastID) and SNPs (using TachysSTR). The TachysSTR program also implements the identification of closely related individuals for familial searching. Today, this method is the fastest in the world for comparing DNA samples against millions of reference profiles in forensic DNA databases. This capability is crucial for conducting timely forensic investigations,

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