Structures for Lossless Ion Manipulations (SLIM)

Organization: Pacific Northwest National Laboratory
Year: 2017

Structures for Lossless Ion Manipulations (SLIM) is a versatile, high-throughput and ultrahigh sensitivity and resolution analytical technology that enables never-before-possible measurements and studies across many fields including medicine. At 1,000 times faster than current liquid chromatography methods (seconds vs. hours), the technology’s sensitivity can identify trace amounts of similar molecules with different structures in even complex samples containing many different compounds. SLIM can identify such differences in samples as small as a single cell. The combination of increased throughput, sensitivity, and resolution makes SLIM a disruptive technology that could change how biological samples such as blood, tissue and urine are analyzed. SLIM can be used in clinical chemistry and therapeutic drug monitoring, providing new capabilities or replacing currently unreliable immunoassays. It can also enhance drug discovery by detecting molecules with different structures that affect toxicity, identifying therapeutic targets and confirming metabolism. As a standalone ion separation instrument, it could analyze tumor samples to predict stages of disease progression, track biomarkers to monitor health and diagnose diseases rapidly and accurately.