iSmartweaR is ITRI’s truly practical solution to address the problem of correct detection of vital sign signals from the body of a smart clothing wearer. It incurs virtually no negative issue in comfort and convenience. Smart clothing provides a means for the collection of a wearer’s basic vital signs of pulse and respiration rates. Such data can be used as the basis for analysis to provide useful reference information such as calories burned to the wearer regarding his or her general biological conditions during, for example, exercise sessions. iSmartweaR constitutes the backbone of a whole spectrum of healthcare assistance applications. They include general health monitoring applications requiring no FDA regulations such as playing the role of an exercise companion to provide basic guidance for effective exercise sessions.