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The PHOTON II is used with single crystal X-ray diffraction systems for crystallographic 3D structure determination of small molecules and macromolecules. Crystallography is the most unambiguous method for determining structures of small molecules and macromolecules and single-crystal X-ray diffraction provides accurate and precise measurements of molecular dimensions in a way that no other science can begin to approach. The PHOTON II detector’s primary function is to accurately and precisely record the position and intensity of an X-ray diffraction pattern form a single-crystal diffraction experiment. It converts X-rays to visible light in a first step using a scintillator screen. This invention takes home-lab-detector technology to a completely new level with the largest monolithic active area, the highest Detective Quantum Efficiency, the highest speed, and the highest dynamic range.