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The Monowave 50 Synthesis Reactor is a modern, easy-to-use ("plug & play") and ultra-compact conventionally heated reactor for synthesis applications performed under sealed vessel conditions, i.e., high temperatures and pressures. The instrument is operated with a 10 milliliters borosilicate glass reaction vial and manually closed by a cavity cover that includes an integrated and active pressure sensor. An efficient magnetic stirring device is built in to ensure efficient agitation of reaction mixtures, while an integrated contact sensor for temperature monitoring accurately monitors and controls the progress of experiments. Automatic cooling of the reaction vials is achieved via an integrated heat exchanger.