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The analysis of complex, fatty samples is one of the biggest challenges faced by analysts, especially as it relates to multi-residue analysis in foods. To date, laboratories have implemented time and labor intensive protocols or have learned to live with the analytical variability and instrumental degradation caused by the most challenging component of complex food samples, lipids. The Bond Elut Enhanced Matrix Removal-Lipid (EMR-Lipid) represents the next generation of sample preparation technology, providing selective lipid removal for complex samples without analyte retention. EMR-Lipid is available in a convenient dispersive solid phase extraction format and is amenable to widely accepted workflows such as QuEChERS and protein precipitation.