Regenerating Suppressor Design

Organization: Thermo Fisher Scientific
Co-Developer(s): Kannan Srinivasan, Principal Developer, Sheetal Bhardwaj, Glenn Kuse, Rong Lin, John Madden, Rob Persson, Chris Pohl
Year: 2014

2014 R&D 100 Winner Suppressors, first invented in 1975 by Hamish Small, are used in ion chromatography (IC) to convert the eluent to a weakly dissociated form so the analyte ions can be detected with high sensitivity. Early suppressors were, from a regeneration perspective, batch mode devices that subsequently evolved to a continuous mode device that was regenerated with chemical reagents. Today, electrolytic regeneration is the preferred means of providing regenerate ions. The technology uses the electrolysis reaction to generate the ions required for suppression. Further, the use of suppressed eluent for providing the water required for electrolysis resulted in significant ease of use.

Thermo Fisher Scientific’s Thermo Scientific Dionex ERS 500 Electrolytically Regenerated Suppressor is a significant leap in electrolytic suppressor product design. The Dionex ERS 500 is the first fully regenerated high-capacity membrane suppressor that eliminates traditional gaskets and the need for frequent off-line regeneration. The new design, comprising two ion exchange membranes and two flanking regenerate channels, allows for operation at high pressures not feasible with current suppressors. The device has a unique fluid channel design that preserves column efficiency and is compatible with 4-µm particle IC columns for fast and high-resolution separations.

Technology Electrolytically regenerated suppressor

DevelopersThermo Fisher Scientific

Development Team

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Thermo Fisher Scientific's Thermo Scientific Dionex ERS 500 Electrolytically Regenerated Suppressor development team (l-r): Todd Rosenbaum, John Madden, Sheetal Bhardwaj, Kannan Srinivasan, Chris Pohl, Rong Lin, Rob Persson and Glenn Kuse.















The Thermo Scientific Dionex ERS 500 Electrolytically Regenerated Suppressor Development Team from Thermo Fisher Scientific Kannan Srinivasan, Principal Developer Sheetal Bhardwaj Glenn Kuse Rong Lin John Madden Rob Persson Chris Pohl